Or, like, "don't be bringing that nonsense around here!" ie, the topic or opinion is unacceptable to the other person, or completely inappropriate, and they want that conversation to go away and never come back.

Example:
"You wanna run away with me?"
"Take a hike! I don't even like you that much, and I've got responsibilities here."

It was common parlance when I was growing up, but nowadays I think people would be more likely to use a sarcastic "Uh, no!" in the same sentence. So picture it in the same kind of tone, if you're taking that interpretation of the prompt.